网站地图 加入收藏 中文 English
 
首页 中心概况 组织机构 研究队伍 科学研究 人才培养 交流合作 支撑服务 人才招聘 下载专区 联系我们
当前位置:首页 - 研究队伍
刘翔宇

刘翔宇

 

电子邮件:liu_xy@mail.tsinghua.edu.cn

电话:86-10-62793589(实验室)

 

研究方向:  

  G蛋白偶联受体(GPCR)的结构生物学研究以及基于结构的药物开发。以结构生物学为主要手段探究GPCR信号传导以及调控的分子机理,并基于结构设计开发GPCR药物。此外还关注新型GPCR药物筛选方法的开发。

 

代表性科研论文:

1. Xinyu Xu*, Jonas Kaindl*, Mary J. Clark*, Harald Hübner, Kunio Hirata, Roger K. Sunahara#, Peter Gmeiner#, Brian K. Kobilka, Xiangyu Liu#. Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR. Cell Research (2021) 31, 569-579. (#co-corresponding author)

 

2. Xiangyu Liu*, Jonas Kaindl*, Magdalena Korczynska, Anne Stößel, Daniela Dengler, Markus Stanek, Harald Hübner, Jake Mahoney, Mary J. Clark, Rachel Ann Matt, Xinyu Xu, Kunio Hirata, Brian K. Shoichet, Roger K. Sunahara#, Brian K. Kobilka#,Peter Gmeiner#. Discovery of an allosteric modulator binding to a conformational hub in the β2 adrenergic receptor. Nature Chemical Biology (2020) 16, 749-755.(*co-first author)

 

3. Xiangyu Liu*, Ali Masoudi*, Alem W. Kahsai*, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, Kunio Hirata, Rishabh K. Simhal, Allison M. Schwalb, Paula K. Rambarat, Seungkirl Ahn, Robert J. Lefkowitz#, Brian Kobilka#. Mechanism of β2AR regulation by an intracellular positive allosteric modulator. Science (2019) 364 (6447), 1283-1287. (*co-first author)

 

4. Xiangyu Liu*#, Xinyu Xu*, Daniel Hilger*, Philipp Aschauer, Johanna K.S. Tiemann, Yang Du, Hongtao Liu, Kunio Hirata, Xiaoou Sun, Ramon Guixà-González, Jesper M. Mathiesen, Peter W. Hildebrand, Brian K. Kobilka#. Structural insights into the process of GPCR-G protein complex formation, Cell (2019) 177(5), 1243-1251. (*co-first author, #co-corresponding author)

 

5. Hongtao Liu*, Josefa Hofmann*, Inbar Fish*, Benjamin Schaake, Katrin Eitel, Amelie Bartuschat, Jonas Kaindl, Hannelore Rampp, Ashutosh Banerjee, Harald Hübner, Mary J. Clark, Sandra G. Vincent , John T. Fisher, Markus R. Heinrich, Kunio Hirata, Xiangyu Liu#, Roger K. Sunahara, Brian K. Shoichet#, Brian K. Kobilka#, Peter Gmeiner#. Structure-guided development of selective muscarinic M3 acetylcholine receptor antagonists. PNAS (2018) 115(47):12046-12050. (#co-corresponding author)

 

6. Xiangyu Liu*, Seungkirl Ahn*, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, A. J. Venkatakrishnan, Ali Masoudi, William I. Weis, Ron O. Dror, Xin Chen, Robert J. Lefkowitz# & Brian K. Kobilka#. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure, Nature (2017) 548, 480-484. (*co-first author)

 

7. Pontus Gourdon*, Xiang-Yu Liu*, Tina Skjørringe, J. Preben Morth, Lisbeth Birk Møller#, Bjørn Panyella Pedersen & Poul Nissen#. Crystal structure of a copper-transporting PIB-type ATPase, Nature (2011) 475, 59-64. (*co-first author)

 

8. Yi-He Huang*, Xiang-Yu Liu*, Xiao-Xia Du, Zheng-Fan Jiang & Xiao-Dong Su. The Structural Basis for the Sensing and Binding of Cyclic di-GMP by STING, Nature Structural & Molecular Biology (2012) 19, 728–730. (*co-first author)

 

 

版权所有 999.8vnsr威尼斯人网站有限责任公司 京ICP备15006448号-5