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宋艳

 

 

宋艳

 

电子邮件:yan.song@pku.edu.cn

电话: +86-10-62752120

实验室主页: http://www.yansonglab.org

 

研究方向

课题组主要致力于探索干细胞谱系内细胞命运及时、精确决定的分子调控机理,以及这些关键决策事件发生错误如何导致发育异常和疾病发生。时间和空间信号如何有机耦合并决定细胞命运一直是发育生物学领域重要的未解之谜。快速分裂的神经干细胞谱系为研究干细胞命运决定的时程调控提供了独特而理想的模型。通过将完整脑神经干细胞谱系延时成像技术与强大的果蝇及小鼠遗传学、生物化学、细胞生物学、液-液相分离及基因组学手段相结合,揭示时空信号调控干细胞谱系内关键细胞命运决策事件的重要分子机理。

代表性论文

1. Liu X.#, Shen J.#, Xie L., Wei Z., Wong C., Li Y., Zheng X., Li P. and Song Y.* (2020) Mitotic implantation of the transcription factor Prospero via phase separation drives terminal neuronal differentiation. Developmental Cell, 52(3), 277-293 [Featured article].

2. Li B.#, Wong C.#, Gao S.M., Zhang R., Sun R., Li Y. and Song Y.* (2018) The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. Elife 2018;7;e38181

3. Xu K., Liu X., Wang Y., Wong C. and Song Y.* (2018) Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming. Elife 2018;7:e33934

4. Liu K., Shen D., Shen J., Gao S.M., Li B., Wong C., Feng W. and Song Y.* (2017) The super elongation complex drives neural stem cell fate commitment. Developmental Cell, 40(6), 537-551 [Cover article].

5. Liu K., Xu K. and Song Y.* (2019) Faster, Higher, Stronger: Timely and robust cell fate/identity commitment in stem cell lineages. Open Biology, 9: 180243. [Invited review]

6. Lee K.S.#, Wu Z.#, Song Y., Mitra S.S., Feroze A.H., Cheshier S.H., Lu B.* (2013) Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. Genes & Development, 27(24):2642-7 [Cover article]

7. Song Y. and Lu B.* (2011) Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila. Genes & Development, 25(24):2644-2658.

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