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邱义福

   

邱义福

 

电子邮件: yifu.qiu(at)pku(dot)edu(dot)cn

联系电话:+86-10-62761052

  

研究方向: 

邱义福实验室主要研究代谢应激的细胞分子机制及其生理功能,并利用这些知识开发防治肥胖及相关代谢疾病的新策略。我们综合使用分子、细胞、遗传、代谢和免疫等方法,开展以下三方面研究:1、能量代谢的免疫调节; 2、褐色、米色脂肪的发育和功能;3、脂肪组织的动态重塑。在Cell, Nature, Nature Immunology, Cell MetabolismNature Communications等期刊发表多篇研究论文。

 

代表性科研论文: 

1. Shen H, Huang X, Zhao Y, Wu D, Xue K, Yao J, Wang Y, Tang N, Qiu Y*. (2022) The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis. Nature Communications (Accepted).

2. Xue K, Wu D, Wang Y, Zhao Y, Shen H, Yao J, Huang X, Li X, Zhou Z, Wang Z, Qiu Y*. (2022) The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis. Cell Metabolism (Published online Aug. 16, 2022).

3. Yao J, Wu D, Zhang C, Yan T, Zhao Y, Shen H, Xue K, Huang X, Wang Z, Qiu Y*. (2021) Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation. Nature Immunology, 22, 1268-1279.

4. Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A. (2014) Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat. Cell, 157, 1292–1308.

5. Nguyen KD#Qiu Y#, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature, 480, 104-108. (#equal contribution).

6. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1alpha activation in pancreatic beta-cells. Science Signaling, 3, ra7.

7. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. (2015) Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis. Cell, 160, 74–87.

8. Nguyen KD, Fentress SJ, Qiu Y, Yun K, Cox JS, Chawla A. Circadian gene Bmal1 regulates diurnal oscillations to Ly6Chi inflammatory monocytes. (2013) Science, 341, 1483-1488. (Research article).

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